By udel'nomu vesu in khimicheskom composition body human magnesium zanimaet chetvertoe mesto after sodium, potassium and calcium, its obshchee content dostigaet 25 g, prichem prakticheski ves' magnesium is vnutrikletochnym kationom.
Magnesium sluzhit kofaktorom for more chem 300 enzymes, reguliruiushchikh razlichnye function body. Magnesium igraet vedushchuiu role in energeticheskom, plasticheskom and elektrolitnom obmene, vystupaet in as reguliatora kletochnogo growth, necessary on all etapakh sinteza belkovykh molekul. IN particular, from nalichiia dostatochnogo kolichestva magnesium in body zavisiat normal'noe funktsionirovanie ribosom and sviazyvanie with nimi informatsionnoi RNK – kliuchevogo mekhanizma biosinteza belka. Besides that, magnesium prinimaet uchastie in obmene fosfora, sinteze ATF, reguliatsii glikoliza, postroenii kostnoi tissue and t.d.
This mikroelement vystupaet molekuliarnym stabilizatorom RNK, DNK, ribosom. Thanks to izmeneniiam vnutrikletochnoi kontsentratsii magnesium osushchestvliaetsia kletochnaia bioenergetika, naprimer mitokhondrial'noe dykhanie.
Iavliaias' estestvennym antagonistom calcium, magnesium participates in processes membrannogo transporta, promotes tormozheniiu sokratitel'noi activity gladkikh and poperechno-polosatykh muscles for due to rasslableniia otdel'nykh cells (miotsitov) putem blokady kal'tsiizavisimogo vzaimodeistviia sokratitel'nykh proteins. For predelami cells iony magnesium sposobny blokirovat' neirosinapticheskuiu peredachu, prepiatstvuia osvobozhdeniiu atsetilkholina, and also narushat' produktsiiu kletkami mozgovogo sloia nadpochechnikov katekholaminov, modeliruia thereby most their fiziologicheskuiu reaktsiiu on stressovoe effect.
Imenno therefore magnesium, tormozia development processes vozbuzhdeniia in tsentral'noi nervous sisteme and snizhaia chuvstvitel'nost' body to vneshnim razdrazhiteliam, vypolniaet function estestvennogo antistressovogo faktora.
On tkanevom urovne magnesium sluzhit neobkhodimym komponentom in sinteze paratireoidnogo gormona, participates in reguliatsii produktsii al'dosterona, estrogenov. Which kasaetsia tkanevoi lokalizatsii magnesium, to okolo 60% its obshchego kolichestva nakhoditsia in kostiakh (imenno kletochnyi pul sluzhit osnovnym istochnikom ustraneniia its defitsita), 38% – in miagkikh tkaniakh (in naibol'shikh kolichestvakh – in myshtsakh and liver) and okolo 1-2% – in vnekletochnoi zhidkosti.
Takie faktory, as povyshenie ob'ema tsirkuliruiushchei blood, potreblenie alkogolia, giperkal'tsiemiia, priem diuretikov (prezhde vsego petlevykh, tiazidnykh and osmoticheskikh) mogut narushat' process reabsorbtsii magnesium and sposobstvovat' development its defitsita in body. Sredi other prichin defitsita magnesium sleduet nazvat' nedostatochnoe its postuplenie with pishchei.
Prichinami defitsita magnesium in body mogut byt' also izbytok its prirodnogo antagonista – calcium, alkogolizm, sindrom mal'absorbtsii, in pervuiu ochered' with patologii tonkoi kishki, endokrinnye zabolevaniia (sakharnyi diabet, giperal'dosteronizm, giperfunktsiia thyroid glands), fizicheskoe and/or
psikhologicheskoe perenapriazhenie, beremennost' and laktatsiia.
Sutochnaia potrebnost' in magnii sostavliaet 350-400 mg for muzhchin and 280-300 mg for women. IN to zhe time in period beremennosti and kormleniia grud'iu potrebnost' in magnii uvelichivaetsia on 20-30% – to 340-355 mg (L. Spatling et al., 1989).
Defitsit magnesium can obuslovlivat' development raznykh form patologii: cardiovascular (arterial'naia gipertenziia, aritmii, ishemicheskaia bolezn' heart), endokrinnoi (sakharnyi diabet), psikhonevrologicheskoi (trevozhnost', depressiia, golovokruzhenie, migren', rasstroistva pamiati, sudorozhnyi sindrom).Osobo sleduet otmetit' tiazhest' skrytogo defitsita magnesium, which can proiavliat'sia in forme obshchei astenii, depressii, psikhoemotsional'noi labil'nosti, golovokruzheniia, vegetativno-nevroticheskikh rasstroistv and t.d. Soglasno rezul'tatam riada issledovanii, in bol'nykh, umershikh from infarkta miokarda, content magnesium in cardiac myshtse bylo on 50% nizhe normy, ponizhennoe content this mikroelementa obnaruzhivali also in bol'nykh with gipertonicheskoi and mochekamennoi bolezn'iu.
By dannym statistiki, in zhitelei raionov with ponizhennym soderzhaniem magnesium in pochve chashche vyiavliaiut onkologicheskie zabolevaniia.
Pokazaniia to primeneniiu preparata. Defitsit magnesium, soprovozhdaiushchii takimi simptomami, as: neznachitel'nye narusheniia sleep, povyshennaia razdrazhitel'nost', slabaia trevoga, povyshennaia utomliaemost', spazm ikronozhnykh muscles.
